hrp0092lb-27 | Late Breaking Posters | ESPE2019

Does Karyotyping and in situ Hybridization from Three Different Germ Layers Elucidate Low Bone Mineral Density in Turner Syndrome?

Soucek Ondrej , Lebl Jan , Zapletalova Jirina , Vrbicka Dita , Adamova Katerina , Prochazka Martin , Klaskova Eva

Background: Turner syndrome (TS) is caused by a total or partial loss of one X chromosome. Typical features include short stature and primary amenorrhoea. In addition, decreasing trabecular bone mineral density (BMD) and increasing cortical BMD during puberty has been reported at the radius. As chromosomal aberration remains a probable cause of bone changes in TS, we aimed to elucidate whether the karyotype differs among the tissues originating from the three ...